Progress in advanced machine intelligence, nano- and biotechnology, additive manufacturing, and the IoT will change both what we mean by health and nutrition and how they are experienced. Stemming from the unprecedented developments that will be required to respond to climate change, resource scarcity, and the desire for longevity, this megatrend will improve health in both the younger and the older years. It will reduce, if not eradicate, some communicable and non-communicable diseases and enhance the sustainable use of and access to water and food.